As the adhesive of tablets and granules, it can be done by wet method, dry granulation or direct pressing method, in most cases, the total amount of $number is about 3%, and the concentration of adhesive is generally $number. According to different materials and accessories, water or alcohol, isopropyl alcohol can be used as solvents respectively. When using direct compression method, its dosage is generally about 5%, can use lactose, Sls sugar, mannitol, microcrystalline cellulose as accessories, but should pay attention to control the moisture content in the ingredients to maintain proper adhesion.
This product as a film coating, often and cellulose derivatives, shellac, high molecular weight polyethylene glycol to improve the strength of the film, adjust the flexibility and solubility of the film, in general, no need to add ester plasticizers.
In the application of water sensitive drug core isolation layer coating, the core can be heated to 30, and then use 10% of the product's non aqueous solution (ethanol, isopropyl alcohol, ethyl acetate or acetone) for spraying, the general spraying volume is 0.4mg Cm2, you can.