CAS Number: [25086-89-9]
Synonym: Copolyvidone
CTFA/INCI: VP/VA Copolymer
Description: Copolymerized polyvinylpyrrolidone (PVP) and vinyl acetate (VA)
Origin: Zhejiang, China
Powder: Yes
As a synergist, copolyvidone has become an important excipient in various industries due to its superior bonding, film-forming and controlled-release properties.
Characteristics
- White powder or granules.
- Soluble in water and a variety of organic solvents, making it suitable for different types of formulations and helping active ingredients dissolve and absorb better.
- Gentle and non-irritating to the skin and mucous membranes, suitable for sensitive skin.
- Strong adhesive properties, can enhance the bonding force between particles and improve the compressibility and strength of solid preparations (such as tablets).
Specification
| Meets the requirements of the latest USP/NF, Ph.Eur. and JPE | |||
| Appearance of solution (10%) | BY5, B5min. | Heavy metals | 20ppm max |
| Aldehydes | 500ppm max. | Loss on drying | 5.0% max |
| Peroxides | 400ppm max. | sulphated ash | 0.1% max |
| Hydrazine | 1ppm max. | K value | 25.2-30.8 |
| Monomers | 0.1% max. | Ethenyl acetate | 35.3%-42.0% |
| Impurity A | 0.5% max. | Nitrogen | 7.0%-8.0% |
Application
- Pharmaceutical field: It is often used in solid preparations such as tablets, capsules, and film coatings as a binder, disintegrant, and controlled-release material.
- Cosmetics: In skin care and hair care products, it acts as a film former and moisturizer to improve the texture and stability of the product while helping the absorption of active ingredients.
- Food industry: Copolyvidone is also used as a food enhancer to improve the texture and stability of food, especially in soft candies and jelly-like foods.
FAQ
1.Why is copolyvidone used in pharmaceutical preparations?
In pharmaceutical preparations, it can improve the adhesion, formability and release control of drugs, help achieve sustained and controlled release effects, and improve the bioavailability of drugs.
2. How does copolyvidone improve drug absorption?
It can help active ingredients enter the body more quickly and effectively by enhancing the solubility and absorption rate of drugs, thereby improving the absorption rate of drugs.
3. What is the role of copolyvidone in cosmetics?
It is used as a film former, humectant and stabilizer to help cosmetics form a uniform protective film, improve texture and moisturizing effect.
4. Is copolyvidone suitable for people with sensitive skin?
It has good biocompatibility and is mild and non-irritating to the skin and mucous membranes, so it is suitable for most skin types, including sensitive skin.
5. How does copolyvidone affect the texture of food?
In the food industry, copolyvidone can improve the texture of food, making it softer and more elastic, especially in soft candies and jelly foods.
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