Drug name: Povidone, Potyvidone
Chemical name: Poly(1-vinyl-2-pyrrolidone)
USP/EP name:Povidone
CTFA/INCI: PVP
CAS N0.:[9003-39-8]
Trade name: Sunvidone-K(STD)
Molecular formula:(C₆H₉NO)n
Kollidone(BASF)
Plasdone(ISP)
Polyvinylpyrrolidone (PVP), medically known as povidone, is a non-ionic water-soluble polymer compound. It is the most distinctive and most deeply studied type of N-vinylamide polymers, and has an 80-year commercial history.
It has now developed into a class of polymers including homopolymers, copolymers, cross-linked polymers and polymer complexes, which are divided into three types: non-ionic, cationic and anionic, and three grades: industrial grade, pharmaceutical grade and food grade. The molecular weight ranges from thousands to millions. Due to its excellent and unique properties, it is widely used in various industries and scientific research departments around the world.
Characteristics
White or very light yellow free-flowing powder or clear solution.
With characteristic odor.
The powder is hygroscopic and soluble in water, ethanol and other organic solvents.
Specification
| SUNVIDONE K | K15 | K17 | K25 | K30 | K90 |
| Appearance (characters) | White or light yellow powder with characteristic odor | Clear solution | |||
| K Value (K Value) | 12.75-17.25 | 15.3-18.5 | 22.5-27.0 | 27.0-32.4 | 81.0-97.2 |
| Water, % (Water) | ≤5.0 | ||||
| PH value (10% aqueous solution) | 3.0-7.0 | 7.0-9.0 | |||
| Residual aldehyde, % (NVP) | ≤0.2 | ≤0.1 | |||
| Aldehyde, % (AIdehyde) | ≤0.05 | ||||
| Heavy metals, ppm (as Pb) | ≤10 | ||||
| Hydrazine, pmm (Hydrzine) | ≤1 | ||||
| Peroxide, % (H202) | ≤0.04 | ||||
| Sulfate ash, % (Ashes) | ≤0.1 | ||||
| Ignition residue, % (Residues on iginition) | ≤0.1 | ||||
| Nitrogen content, % (Nitrogen) | 11.5-12.8 | ||||
Application
●High-efficiency adhesives are preferred for wet granulation:
K30- general purpose; K25- suitable for lower viscosity, more dosage
K90- high adhesion, less dosage
●Solubilizers, dispersants, suspension stabilizers: K17- for injections, etc.
K25, K30- for oral or topical preparations
●Film formers and pigment dispersants: K25, K30- for sugar coating and film coating
●Viscosifiers: K90- for liquid preparations
25KG, 50KG fiberboard barrels
FAQ
1.What is the optimal dosage of PVP K30 in tablets?
The optimal dosage depends on the specific formulation and preparation requirements, usually between 1% and 10%, which needs to be determined experimentally.
2.Can PVP K30 be mixed with other materials?
Yes, PVP K30 can be mixed with a variety of other medicinal ingredients and polymers to enhance the performance of tablets.
3.Will PVP K30 affect its performance at high temperatures?
PVP K30 may degrade at high temperatures, so attention should be paid to temperature control during processing to avoid exceeding its thermal stability.
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