Chemical name: Povidone K17, also known as polyvinylpyrrolidone K17.
Molecular weight: Compared with other types of povidone, K17 has a specific molecular weight range, but the specific v
●Characteristics
1. Good solubility: Povidone K17 has good solubility under certain conditions. For example, in polyethylene glycol 2000, the solubility is about 70% at 65°C, and the solubility decreases with the increase of polyethylene glycol molecular weight.
2. Ability to form hydrogen bonds: It can form intermolecular hydrogen bonds with other substances. For example, when forming a solid dispersion with a drug, it affects the physical and chemical properties of the drug through hydrogen bonding.
Uses
Drug stability:
In nimodipine - polyethylene glycol 2000 solid dispersion, povidone K17 stops drug recrystallization, ensuring storage stability.
Pharma use:
In pharma, as a multi - functional excipient, it boosts drug bioavailability and stability, improves preparation properties, adjusts drug release, and lengthens liposome circulation in the body.
Oral insulin liposomes:
In mouse oral insulin liposomes, it inhibits pepsin, with the effect increasing by molecular weight. PVP - K30 in insulin liposomes is better than PVP - K17 and PVP - K90 for oral insulin liposome hypoglycemic effect, yet K17 also helps.
Drug solid dispersion:
When making solid dispersions, it bonds with drugs like piroxicam via hydrogen, alters drug crystal structure, and raises drug dissolution. Low - MW povidone K17 is better than high - MW povidone K - 90 for piroxicam dissolution.
FAQ
Q: What is its chemical structure?
A: It is a linear polymer connected by N-vinyl-2-pyrrolidone repeating units. The molecular structure contains a lactam ring, which gives it unique physical and chemical properties, such as hydrophilicity and film-forming properties.
Q: In what fields is PVP K17 mainly used?
A: In the pharmaceutical field, it can be used as a binder and disintegrant for tablets, a glidant for capsules, and can also be used to prepare drug sustained-release preparations; in the cosmetics field, it is used as a film-forming agent, thickener, and stabilizer to improve product texture and stability; in the food industry, it can be used as a clarifier for beer, juice, etc. to remove impurities such as polyphenols and proteins.
Q: How to ensure the quality of polyvinylpyrrolidone k17 products?
A: We strictly follow international quality standards for production, starting from the purchase of raw materials, using advanced technology and strict quality inspection system in the production process. Each batch of products is tested for multiple indicators, including K value, purity, heavy metal content, etc., to ensure stable and reliable product quality.
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