Synonym: Copolyvidone
CTFA/INCI: VP/VA Copolymer
CAS Number: [25086-89-9]
It is used as a binder, granulating agent, retarder and film in the pharmaceutical industry.
Forming agent in drugs.
Characteristics
White or slightly yellow, free-flowing powder with a light characteristic odor and almost no taste.
Soluble in all hydrophilic solvents. Solutions with concentrations exceeding 10% can be prepared in the following solvents: water; ethanol; isopropanol; methylene chloride; glycerol; propylene glycol; less soluble in the following solvents: ethers; cyclic, aliphatic and alicyclic hydrocarbons.
Excellent adhesion ensures the structural stability of the tablets and reduces the risk of breakage during production and transportation.
Specification
| Meets the requirements of the latest USP/NF, Ph.Eur. and JPE | |||
| Appearance of solution (10%) | BY5, B5min. | Heavy metals | 20ppm max |
| Aldehydes | 500ppm max. | Loss on drying | 5.0% max |
| Peroxides | 400ppm max. | sulphated ash | 0.1% max |
| Hydrazine | 1ppm max. | K value | 25.2-30.8 |
| Monomers | 0.1% max. | Ethenyl acetate | 35.3%-42.0% |
| Impurity A | 0.5% max. | Nitrogen | 7.0%-8.0% |
Application
Copovidone has a wide range of applications in the pharmaceutical industry, including:
Pharmaceutical Tablets: In the production of pharmaceutical tablets, it is used as a binder to ensure the uniformity and dosage accuracy of tablets.
Granules and Capsules: In the production of granules and capsules, it can be used as a binder and thickener to improve the fluidity and stability of the product.
Liquid Preparations: In liquid preparations, it is used to thicken and stabilize the formula to make the product easier to use.
Packaging
20KG or 25KG net weight cardboard drum or PP drum.
Note
When using, you need to pay attention to its dosage and compatibility with other excipients. During the production process, you must ensure compliance with relevant regulations and standards to ensure the safety and effectiveness of the final product.
FAQ
1.In which pharmaceutical preparations is Copovidonee mainly used?
It is commonly used as an excipient for tablets, capsules, granules and other drugs as a binder, film-forming agent or controlled-release agent. It can also be used to improve drug solubility and bioavailability.
2. Is Copovidonee suitable for controlled-release drugs?
Yes, it can be used as a controlled-release agent to adjust the drug release rate through its film-forming properties and water solubility. It is particularly suitable for sustained-release and controlled-release preparations.
3. How is Copovidonee different from other excipients?
Compared with traditional excipients, it has higher mechanical strength and versatility, and has better water resistance and thermal stability, which can meet the needs of more complex drug preparations.
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