Vinylpyrrolidone-Copolymer is a type of high molecular weight polymer formed by polymerization of N-vinylpyrrolidone (NVP) and other monomers. NVP has unique chemical activity and can copolymerize with a variety of monomers (such as vinyl acetate) to construct molecular structures with different properties.
SunvidonEVA meets the requirements of the latest usp,ep.And jp
| Appearance of solution(10%) | BY₅,B₅min. | Impurity C | 10ppm max. |
| K value | 25.2-30.8 | Heavy metals | 20ppm max |
| Aldehydes | 500ppm max. | Loss on drying | 5.0%max |
| Peroxides | 400ppm max. | sulphated ash | 0.1%max |
| Hydrazine | 1ppm max. | Ethenyl acetate | 35.3%-42.0% |
| Impurity A | 0.5%max. | Nitrogen | 7.0%-8.0% |
| ImpurityB | 10ppm max. |
Characteristics
White or slightly yellow, free-flowing powder with a faint characteristic odor, almost odorless.
Sunvidone VA is easily soluble in all hydrophilic solvents. Solutions with concentrations exceeding 10% can be prepared in water, ethanol, isopropanol, dichloromethane, glycerol, propylene glycol, and are less soluble in ethers, cycloaliphatic and alicyclic hydrocarbons
| --Dry binder for direct compression | Between 2%and 5%,as a proportion of the final weightof the |
| --Wet granulation | preparation,is usually used. |
| --Film-coating | Sunvidone⁸VA forms films that are soluble at all pH values |
| --Subcoating/Sugar-coating | Sunvidone VA is used in sugar-coating to improve the adhesion of the coating to the surface of the tablet core |
| --Sprays | increase the capacity of the coating solution for pigments |
| --Controlled-release preparations | improve their dispersibility. |
| PACKAGES | 25KG net in fiber drum or PP drum |
About our company
Huzhou Sunflower Pharmaceutical Co., Ltd. (Sunflower Pharmaceutical) was established in 2015 based on the pharmaceutical department of Hangzhou Sunflower Technology Development Co., Ltd. Sunflower Pharmaceutical inherited all the assets of Hangzhou Sunflower Technology Development Co., Ltd., such as equipment, technology, products, team, management and trademarks. The company has an annual production capacity of 1,000 tons of low molecular weight povidone (povidone K12, K15, K17, K25 and K30) and an annual production capacity of 600 tons of high stability povidone in accordance with GLP requirements. The new high molecular weight plant (povidone K60, K90, K120) has started operation in July 2022. The new production capacity will reach 3,000 tons per year. With these new capacities put into production, we will become the largest manufacturer of PVPK90 in China. Our business company adheres to the "people-oriented, innovation-oriented" business philosophy, continuously improves the professionalism, applicability and superiority of its products, and is committed to becoming the strategic goal of the company's development. We are willing to establish long-term cooperative relationships with customers at home and abroad, provide you with high-quality products and sincere services, and create spiritual and material wealth with you.
FAQ
Q: How does it perform in terms of environmental protection? Is it environmentally friendly?
A: Very friendly. First of all, its synthesis process follows the concept of green chemistry and minimizes the generation of harmful by-products. Secondly, in the terminal use of the product, such as in the application of coatings, it has less volatile organic components, which reduces the pollution to the atmosphere; when used in the synthesis of some degradable materials, it can gradually decompose in the natural environment over time, without bringing long-term burden to the soil, etc., which is completely in line with the current environmental protection trend.
Q：If you want to make a drug containing PVP homopolymer, what guarantees are needed in the selection of ingredients?
A:When making drugs containing PVP homopolymer, the purity of PVP must be strictly controlled to meet the high standards of drugs, and the residual monomer content must be strictly controlled; its molecular weight distribution must be accurately controlled to ensure stable drug dissolution and release, such as oral drugs that use appropriate molecular weight to achieve uniform gastrointestinal drug release; the selected PVP and other ingredients and excipients of the drug must have good chemical and physical stability, such as the injection formula to ensure that the solution is clear and the drug effect is long-lasting; and the microbial limit must meet the standard, and production and packaging must be carried out in accordance with GMP specifications to eliminate contamination and ensure drug safety.
Q:For drugs that require suspension stability, what key roles can PVP play?
A:When drugs require suspension stability, PVP plays an outstanding role. On the one hand, it can be evenly dispersed in the solution system with good solubility to form a viscous environment to hinder the sedimentation of drug particles, so that the suspension drugs can be suspended stably and the dosage can be taken accurately during storage and use. On the other hand, its molecules are adsorbed on the surface of drug particles, and the steric hindrance effect is used to prevent the particles from agglomerating and agglomerating, so that some antibiotic suspension drugs can solve the storage agglomeration problem, improve stability and extend shelf life.
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