Synonyms: Povidone; Polyvinylpyrrolidone
International Chemical Name: PVP
CAS Number: [9003-39-8]
USP/EP name:Povidone
Molecular formula:(C₆H₉NO)n
They have a slight characteristic odor and almost no taste.
As a pharmaceutical excipient, Povidone has become an indispensable and important ingredient in the modern pharmaceutical industry with its unique properties and wide application fields. Whether it is to improve the bioavailability of drugs or to enhance the stability of drugs, Povidone has demonstrated its outstanding value.
Characteristics
White non-powdered hygroscopic powder, easily soluble in ethanol and methanol, slightly soluble in acetone.
Water solubility: Povidone is a water-soluble polymer that can dissolve quickly in water to form a transparent colloidal solution.
Biocompatibility: Povidone is considered safe in the biomedical field and has good biocompatibility. It can be well combined with human tissue and is suitable for use in the pharmaceutical field.
Adhesion: As an adhesive, povidone can effectively bond drug particles together to improve the stability and bioavailability of drug.
Specification
| SUNVIDONE | K15 | K17 | K25 | K30 | K90 |
| Colour (5% in water) min. | BY6, B6 | BY6, B6 | BY6, B6 | BY6, B6 | BY6, B6 |
| K value | 12.8-17.3 | 15.3-18.4 | 22.5-27.0 | 27.0-32.4 | 81.0-97.2 |
| Impurity A, ppm max | 10 | 10 | 10 | 10 | 10 |
| Impurity B, %max | 3 | 3 | 3 | 3 | 3 |
| Formic Acid. %max | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| Peroxides, ppm max | 400 | 400 | 400 | 400 | 400 |
| Aldehyde, ppm max | 500 | 500 | 500 | 500 | 500 |
| Hydrazine, ppm max | 1 | 1 | 1 | 1 | 1 |
Application
Pharmaceutical preparations: Povidone is widely used as a binder for tablets and capsules. In tablets, povidone helps bind powder particles together, enhancing the tablet's strength and hardness. It can also improve the release characteristics of drugs, ensuring the effectiveness of drugs in the body.
Coating agents: In the surface coating of drugs, povidone can be used as a film former to form a protective film that can control the release rate of drugs while protecting them from oxidation and moisture.
Colloids and suspending agents: Povidone is often used to prepare drug suspensions and gels to enhance their consistency and stability. It can help drugs disperse evenly in the solution to ensure consistent dosage.
Topical medications: In some topical medications, povidone is used as a thickener and stabilizer to improve the application effect of drugs and adhesion to the skin.
FAQ
1.Can povidone be used in food and cosmetics?
Although povidone is mainly used in pharmaceuticals, it can also be used in food and cosmetics as a thickener and stabilizer in some cases, provided that relevant safety standards are met.
2. How does povidone affect the release characteristics of drugs?
Povidone can control the release rate of drugs by forming a uniform coating and increasing the adhesion of particles.
3. What are the advantages of povidone compared with other excipients?
Povidone has excellent water solubility and adhesion, is compatible with a variety of drugs, and its safety and biocompatibility make it an ideal pharmaceutical excipient.
4. Does the use of povidone require special formulation adjustments?
When using povidone, it may be necessary to adjust its concentration and the ratio of other excipients according to specific formulation requirements.
5. What is the production process of povidone?
Povidone is usually made by polymerizing vinylpyrrolidone monomers, and the production process should be strictly controlled to ensure the purity and performance of the product.
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